منابع مشابه
TP53 and liver carcinogenesis.
Primary hepatocellular carcinoma (HCC) is one of the most common malignancies and has the fourth highest mortality rate worldwide. The major risk factors, including chronic infections with the hepatitis B or C virus, are exposure to dietary aflatoxin B1(AFB1), vinyl chloride, or alcohol consumption. Southern China and sub-Saharan Africa have the highest dietary AFB1 exposure, making it and hepa...
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Imatinib is an orally administered tyrosine kinase inhibitor which inhibits the Bcr-Abl protein-tyrosine kinase with high selectivity. Imatinib is rapidly absorbed from the gut, after oral intake and has an almost absolute bioavailability of 98%. The metabolism of imatinib is mediated by the cytochrome P450 (CYP) isoenzymes in the liver and gut wall. CGP74588 is a major active metabolite of ima...
متن کاملLiver Development, Regeneration, and Carcinogenesis
The identification of putative liver stem cells has brought closer the previously separate fields of liver development, regeneration, and carcinogenesis. Significant overlaps in the regulation of these processes are now being described. For example, studies in embryonic liver development have already provided the basis for directed differentiation of human embryonic stem cells and induced pluri...
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Bacterial biofilms in the colon alter the host tissue microenvironment. A role for biofilms in colon cancer metabolism has been suggested but to date has not been evaluated. Using metabolomics, we investigated the metabolic influence that microbial biofilms have on colon tissues and the related occurrence of cancer. Patient-matched colon cancers and histologically normal tissues, with or withou...
متن کاملCitric Acid Metabolism in Carcinogenesis and Its
Previous studies on the calcium metabolism of epidermis undergoing carcinogenesis (@2,10, 11) have suggested the possibility that the action of one or more calcium-binding substances may ac count for the decreased calcium content in hyper plastic epidermis and in a squamous-cell carcinoma. The present investigation has been devoted to a study, in normal and cancerous tissues of the mouse, of th...
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ژورنال
عنوان ژورنال: The Japanese Journal of SURGICAL METABOLISM and NUTRITION
سال: 2014
ISSN: 0389-5564,2187-5154
DOI: 10.11638/jssmn.48.4_101